Extrachromosomal circular DNA: Current status and future prospects

Extrachromosomal circular DNA: Current status and future prospects

Blog Article

Extrachromosomal circular DNA (eccDNA) is a double-stranded DNA molecule found in various organisms, including humans.In the past few decades, the research on eccDNA has mainly focused on cancers and their associated diseases.Advancements in modern omics technologies have reinvigorated research on eccDNA and shed light on the role of these molecules in a range of diseases and normal cell Bosch SMS46MI01G Freestanding Dishwasher Stainless Steel phenotypes.In this review, we first summarize the formation of eccDNA and its modes of action in eukaryotic cells.We then outline eccDNA as a disease biomarker and reveal its regulatory mechanism.

We finally discuss the future prospects of eccDNA, including basic research and clinical application.Thus, with the deepening Floor Lamp of understanding and exploration of eccDNAs, they hold great promise in future biomedical research and clinical translational application.